NAVIGATION

Tel:

Fax:

Email: For product inquiries or a copy of our product catalog, please use our online system or send an email to .

1-Octen-3-ol

Name: 1-Octen-3-ol
SKU: ACMA00045788
Rating: 5 (1 reviews)

PRICE INQUIRY

Catalog NumberACMA00045788

CAS Number3391-86-4

CategoryFatty-acid Products

Synonyms

Vinyl amyl carbinol

IUPAC Name

Oct-1-en-3-ol

Molecular Weight

128.21

Molecular Formula

C8H16O

InChI

InChI=1S/C8H16O/c1-3-5-6-7-8(9)4-2/h4,8-9H,2-3,5-7H2,1H3

InChI Key

VSMOENVRRABVKN-UHFFFAOYSA-N

Boiling Point

84-85 °C

Melting Point

-49 °C

Flash Point

142 °F

Purity

98%+

Density

0.83 g/mL at 25 °C(lit.)

Solubility

Insoluble in water, soluble in oils

Appearance

Colorless to pale yellow liquid

Exact Mass

128.12011513

Physical State

Liquid

Download COA Download MSDS

Case Study

1-Octen-3-ol in the Study of Neurodegenerative and Depression-Associated Neural Injury in Rats

Song, Hao, et al. NeuroToxicology 108 (2025): 81-93.

1-Octen-3-ol, a volatile compound naturally occurring in fungi and plants, has been implicated in neurodegenerative processes. In this study, aerosolized 1-octen-3-ol was administered to depressive model SD rats to elucidate its effects on neural injury and neurophysiology. Behavioral assessments revealed a significant decrease in sucrose preference (42.9 %) and spontaneous exploration, alongside increased immobility in the forced swim test, indicating pronounced depressive-like behavior.
Mechanistically, 1-octen-3-ol disrupted blood-brain barrier integrity by downregulating tight junction proteins Occludin and Claudin-1 and triggered neuroendocrine dysregulation via elevated corticosterone secretion. Monoamine neurotransmitters, including serotonin and norepinephrine, and amino acid neurotransmitters, such as 5-hydroxytryptophan, were significantly reduced. Concurrently, pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) were upregulated, reflecting activation of the TLR4/NF-κB inflammatory pathway, while antioxidant Nrf2/HO-1 signaling was suppressed.
Further molecular analyses showed decreased expression of synaptic proteins (PSD-95, Synapsin, NMDA1) and neurotrophic factors (NT3, NT4), culminating in impaired neuroplasticity. These combined effects demonstrate that 1-octen-3-ol exacerbates neural injury in depressive conditions by promoting oxidative stress, inflammation, and synaptic dysfunction.
This study establishes 1-octen-3-ol as a potent experimental agent for modeling neurodegeneration and depression-related neural injury in rodents, providing a mechanistic basis for its neurotoxic effects and highlighting its utility in preclinical neuropharmacological and toxicological investigations.

1-Octen-3-ol in the Preparation of Surfactant-Free Microemulsions for Enhanced Hydrophobic Compound Solubilization

Zhang, Xiaoyu, et al. Journal of Molecular Liquids 300 (2020): 112278.

1-Octen-3-ol, a naturally occurring volatile compound, was employed as the oil phase in the formulation of surfactant-free microemulsions (SFME) using ethanol as a double solvent. The ternary phase diagram of the 1-octen-3-ol-based SFME system revealed three distinct phase regions-oil-in-water (O/W), bicontinuous (B.C.), and water-in-oil (W/O)-characterized via conductivity measurements and UV-vis spectroscopy. Dynamic light scattering (DLS) analyses indicated double exponential decay patterns, while negative-staining transmission electron microscopy confirmed spherical droplet structures in O/W and W/O phases and a bicontinuous network in the B.C. phase.
Functional evaluation of the SFME demonstrated efficient surfactant-free solubilization of hydrophobic bioactives. In the W/O SFME, riboflavin exhibited significantly enhanced solubilization, comparable to conventional surfactant-based microemulsions. Similarly, curcumin solubilized in the O/W SFME reached a concentration of 17.65 mg/mL, representing an approximate 10,000-fold increase relative to its aqueous solubility. Furthermore, the encapsulated curcumin displayed improved photostability and thermal stability compared with its solution in water.
This study highlights the application of 1-octen-3-ol as a sustainable oil phase in the preparation of SFME systems, enabling high-efficiency solubilization of hydrophobic compounds without surfactants. These findings offer a versatile platform for developing stable, biocompatible microemulsion systems for pharmaceuticals, nutraceuticals, and other hydrophobic bioactive delivery applications.

1-Octen-3-ol in the Preparation of Agar/Curdlan Composite Hydrogels for Induced Resistance Against Peach Fruit Pathogens

Wang, Xiaozhao, et al. International Journal of Biological Macromolecules 251 (2023): 126411.

To develop a controlled-release system for 1-octen-3-ol, agar/curdlan composite hydrogels were prepared using a stepwise heating and mixing procedure. Briefly, agar (2 g), curdlan (2 g), or a combination of agar (1 g) and curdlan (1 g) were dissolved in 100 mL of distilled water and stirred at 90 °C for 30 min to ensure complete solubilization. Following gel formation, 1% 1-octen-3-ol, 1% glycerol, and 0.1% Tween 80 (w/v) were incorporated under continuous stirring to promote uniform distribution of the volatile compound within the polymeric network. The resulting solutions were poured into 9 cm Petri dishes (30 mL per dish) and allowed to solidify at 25 °C. Control gels without 1-octen-3-ol were prepared in parallel.
Structural characterization indicated that 1-octen-3-ol facilitated interactions between agar and curdlan, forming a porous microstructure favorable for retention and sustained release. Mechanical testing confirmed enhanced gel stability for the composite formulation. in vitro antifungal assays demonstrated effective inhibition of Monilinia fructicola and Rhizopus stolonifer, while in vivo application on peach fruits showed pronounced suppression of brown rot and soft rot.
This experimental design demonstrates a reproducible methodology for embedding volatile bioactive compounds in biopolymer hydrogels, providing controlled release and improved postharvest disease resistance.

Custom Q&A

What is the molecular formula of 1-Octen-3-ol?

The molecular formula of 1-Octen-3-ol is C8H16O.

What is the molecular weight of 1-Octen-3-ol?

The molecular weight of 1-Octen-3-ol is 128.21 g/mol.

What is the IUPAC name of 1-Octen-3-ol?

The IUPAC name of 1-Octen-3-ol is oct-1-en-3-ol.

What is the InChI of 1-Octen-3-ol?

The InChI of 1-Octen-3-ol is InChI=1S/C8H16O/c1-3-5-6-7-8(9)4-2/h4,8-9H,2-3,5-7H2,1H3.

What is the InChIKey of 1-Octen-3-ol?

The InChIKey of 1-Octen-3-ol is VSMOENVRRABVKN-UHFFFAOYSA-N.

What is the canonical SMILES of 1-Octen-3-ol?

The canonical SMILES of 1-Octen-3-ol is CCCCCC(C=C)O.

What is the CAS number of 1-Octen-3-ol?

The CAS number of 1-Octen-3-ol is 3391-86-4.

What is the FEMA number of 1-Octen-3-ol?

The FEMA number of 1-Octen-3-ol is 2805.

What is the JECFA number of 1-Octen-3-ol?

The JECFA number of 1-Octen-3-ol is 1152.

What is the Wikipedia page for 1-Octen-3-ol?

The Wikipedia page for 1-Octen-3-ol is "1-Octen-3-ol".

※ Please kindly note that our products are for research use only.

Online Inquiry

Name:

Phone:

Email: *

Quote Number:

Quantity: *

Service & Products of Interest: *

Project Description: