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Phosphatidylserine

Name: Phosphatidylserine
SKU: ACM1446756473
Rating: 5 (1 reviews)

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Catalog NumberACM1446756473

CAS Number1446756-47-3

CategoryPhospholipids

Synonyms

PS; (2S)-2-Amino-3-[[(2R)-2-butanoyloxy-3-propanoyloxypropoxy]-hydroxyphosphoryl]oxypropanoic acid

Molecular Weight

788 (oleoyl)

Molecular Formula

C42H78NO10P(oleoyl)

Purity

>98%

Solubility

Chloroform: Soluble

Appearance

Liquid

Shipping

Room temperature

Stability

≥2 Years

Storage Temperature

-20 °C

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Case Study

Phosphatidylserine for the Improvement of Survival and Cognitive Function in Sepsis and Sepsis-Associated Encephalopathy

Xu, Kejia, et al. Biomedicine & Pharmacotherapy 178 (2024): 117200.

Phosphatidylserine (PS), a phospholipid nutrient integral to neuronal membranes, was evaluated for its therapeutic potential in sepsis and sepsis-associated encephalopathy (SAE) in middle-aged mice. PS was administered for two months following lipopolysaccharide-induced sepsis. Treated mice exhibited a significant increase in survival compared to untreated controls, highlighting PS's protective systemic effects.
Neurobehavioral assessments, including open field and shuttle box tests conducted 45 days post-sepsis, revealed that PS pretreatment mitigated cognitive and behavioral impairments commonly associated with SAE. Histological and molecular analyses at 60 days post-sepsis demonstrated reduced neuronal apoptosis, as indicated by decreased cleaved-caspase 3, alongside lowered glial cell activation markers in PS-treated mice. Additionally, proinflammatory cytokine gene expression in the hippocampus was markedly reduced, suggesting inhibition of the TBK1/NLRP3/ASC signaling pathway as a potential mechanism for neuroprotection.
PS administration also preserved gut integrity, maintaining jejunal morphology and colon ZO-1 expression, while modulating β-diversity of the gut microbiome without altering α-diversity indices. These findings underscore the dual systemic and neuroprotective roles of PS, demonstrating its capacity to enhance survival, reduce neuroinflammation, and preserve cognitive function following sepsis.
Overall, this study establishes PS as a promising preventative and therapeutic agent for sepsis and SAE, with implications for maintaining cognitive function in aging populations. Its FDA-approved status as a dietary supplement further supports its translational potential for clinical applications.

Phosphatidylserine for the Preparation of Anti-Inflammatory Nanoparticles Targeting Acute Lung Injury

Li, Y., Li, H., Hu, Z., Zhang, Y., Ding, X., Huang, X., ... & He, Y. (2025). Journal of Lipid Research, 66(5).

Phosphatidylserine (PtdSer), a membrane phospholipid exposed on apoptotic cells, was employed to engineer macrophage-targeted nanoparticles for the treatment of acute lung injury (ALI). In this study, poly(lactic-co-glycolic acid) (PLGA) nanoparticles were decorated with varying densities of PtdSer (2%, 5%, 10%) to mimic apoptotic cell surfaces, producing low- (L-PSNPs), moderate- (M-PSNPs), and high-density (H-PSNPs) phosphatidylserine nanoparticles. Nanoparticles were prepared via antisolvent precipitation, and dexamethasone (DEM) was co-encapsulated to assess anti-inflammatory efficacy.
in vitro, PSNPs enhanced macrophage phagocytosis and exhibited robust anti-inflammatory activity compared to undecorated PLGA nanoparticles. Dexamethasone-loaded PSNPs further amplified suppression of proinflammatory responses in activated macrophages. in vivo, pulmonary administration of PSNPs demonstrated preferential accumulation in lung macrophages, with H-PSNPs achieving the highest targeting efficiency. DEM-loaded PSNPs markedly reduced pulmonary inflammation, alleviating key ALI symptoms including edema, inflammatory cell infiltration, and cytokine overexpression.
Mechanistic analysis indicated that PtdSer decoration facilitated macrophage recognition via apoptotic cell-mimicking signals, promoting anti-inflammatory signaling and enhanced nanoparticle uptake. These results establish phosphatidylserine as a dual-function moiety: it confers anti-inflammatory properties and enables selective macrophage targeting within inflamed lung tissue.
Overall, this study demonstrates that phosphatidylserine-decorated nanoparticles provide a versatile drug delivery platform for ALI therapy, combining biomimetic targeting and therapeutic efficacy, highlighting its potential in precision nanomedicine applications.

Phosphatidylserine for the Preparation of Alveolar Macrophage-Targeted Immunostimulant Liposomes in Pulmonary Metastasis Therapy

Chen, Xiayun, et al. Nano Today 61 (2025): 102667.

Phosphatidylserine (PtdSer) was utilized to engineer biomimetic liposomes for targeted immunotherapy against pulmonary metastasis. Pulmonary metastases often induce alveolar macrophage (AM) polarization toward the immunosuppressive M2 phenotype, impairing phagocytic clearance of tumor cells. In this study, PtdSer-decorated liposomes were co-loaded with TLR7/8 agonist (R848) and SHP2 inhibitor (SHP099), forming inhalable alveolar macrophage-targeted immunostimulants (I-AM-IMs). Nebulization inhalation facilitated both passive and active delivery to AMs in the lower respiratory tract, enhancing local drug bioavailability while minimizing systemic exposure.
in vitro and in vivo evaluations demonstrated that I-AM-IMs promoted M1 polarization of AMs, restoring phagocytic activity and triggering cytotoxic cytokine release. This macrophage reprogramming directed efficient elimination of metastatic tumor cells and activated CD8⁺ T cell-mediated anti-tumor immunity. Importantly, PtdSer decoration enabled selective recognition by AMs, leveraging their inherent apoptotic cell uptake mechanisms, and amplified the pharmacological effects of R848 and SHP099.
Overall, phosphatidylserine served as a dual-function moiety: facilitating targeted alveolar macrophage delivery and enhancing immunomodulatory activity within the lung microenvironment. The resulting I-AM-IMs demonstrated superior anti-metastatic efficacy, providing a versatile platform for localized pulmonary metastasis immunotherapy. This approach highlights the potential of PtdSer-functionalized nanocarriers in precision immunotherapy and opens new avenues for the treatment of lung-resident malignancies.

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