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SodiuM Lauryl Sulfate, 1 Percent Solution

Name: SodiuM Lauryl Sulfate, 1 Percent Solution
SKU: ACMA00006790
Rating: 5 (1 reviews)

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Catalog NumberACMA00006790

CategoryFatty-acid Products

SodiuM Lauryl Sulfate, 1 Percent Solution

Molecular Weight

288.37927

Molecular Formula

C12H25NaO4S

Download COA Download MSDS

Case Study

Sodium Lauryl Sulfate Used for Modulating the Dissolution Behavior of Lurasidone Hydrochloride via Complex Formation and Gelation

Lin, Zezhi, et al. International Journal of Pharmaceutics 624 (2022): 122035.

Sodium lauryl sulfate (SLS), a common surfactant in dissolution testing, is typically employed to enhance the solubility of poorly water-soluble drugs and maintain sink conditions. However, this study reveals an unexpected inhibitory effect of 0.1% SLS on the dissolution of crystalline lurasidone hydrochloride (LH), a BCS II drug. Detailed characterization using polarized light microscopy (PLM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) confirmed the formation of an insoluble single-phase amorphous LH-SLS complex during dissolution.
This complex arises from multiple intermolecular interactions, including electrostatic forces, tetrel bonding, and hydrophobic effects. The amorphous LH-SLS undergoes a glass transition at 35.2 °C, shifting from a glassy state to a viscous supercooled liquid, resulting in gel formation that significantly suppresses LH dissolution. Intriguingly, the solubility profile of LH in SLS solutions exhibits a V-shaped curve with the critical micelle concentration (CMC) of SLS marking an inflection point. Beyond the CMC, increased micelle formation attenuates gelation, enhancing LH solubility.
A novel mitigation strategy based on competitive molecular interactions was developed, successfully alleviating the surfactant-induced dissolution inhibition. This work advances understanding of surfactant-drug complexation effects and provides practical approaches to optimize dissolution conditions for poorly soluble drugs in the presence of surfactants like sodium lauryl sulfate.

Sodium Lauryl Sulphate Used for the Preparation and Stabilization of Cadmium Sulphide Nanoparticles via Co-Precipitation Method

Muthuvijayan, Santhoshbalaji, et al. Process Biochemistry 138 (2024): 57-66.

This study details the synthesis of cadmium sulphide (CdS) nanoparticles stabilized by sodium lauryl sulphate (SLS) through a co-precipitation method. Initially, 0.1 M cadmium nitrate tetrahydrate (Cd(NO₃)₂·4H₂O) was dissolved in 50 mL distilled water and stirred for 15 minutes at room temperature. Subsequently, a 0.1 M sodium sulphide (Na₂S) solution was slowly added dropwise under continuous stirring, with the reaction mixture maintained at 80°C. The stirring continued for an additional 30 minutes to ensure complete reaction and nucleation of CdS nanoparticles.
Following nanoparticle formation, SLS was introduced at varying concentrations (0.5, 1.0, 1.5, 2.0, and 2.5 g) to the reaction mixture, and stirring was maintained for another 30 minutes. This step facilitated the surface capping and stabilization of the CdS nanoparticles, preventing agglomeration through electrostatic and steric effects. The resulting nanoparticles were then subjected to sequential washing with deionized water, acetone, and ethanol to remove impurities and excess reagents.
Finally, the purified CdS nanoparticles were dried at 180°C for 2 hours to obtain a stable powder form. The experimental protocol was systematically repeated for each SLS concentration to identify the optimal condition that yields nanoparticles with desirable size, morphology, and optical properties. This method highlights the critical role of SLS concentration in modulating nanoparticle synthesis and stability, which is essential for potential applications in photocatalysis and optoelectronic devices.

Sodium Lauryl Sulfate Used for the Preparation of High-Performance Dry-Latex Polymer Particles in Sustained-Release Tablet Coating

Kondo, Keita, Sayaka Ohta, and Toshiyuki Niwa. European Journal of Pharmaceutics and Biopharmaceutics 188 (2023): 125-136.

This study investigates the application of sodium lauryl sulfate (SLS) in modifying ammonioalkyl methacrylate copolymer dry-latex particles to enhance tablet coating performance via a solvent-free, heat-free V-shaped blending process. Aqueous polymer latexes containing various SLS concentrations (0-10% relative to polymer weight) were prepared by mixing with purified water to a 10% solid content, followed by freeze drying (-30 °C, 24 h vacuum sublimation) to obtain dry latex powders (DL). The addition of SLS prevented polymer coagulation during freeze drying, producing loosely structured dry latex particles with improved pulverizability and adhesiveness.
Uncoated tablets were manufactured from acetaminophen, lactose, and microcrystalline cellulose blends, then coated by mixing with DLs in a V-shaped blender at 56 rpm for 12 h at room temperature. Coating efficiency increased with SLS content up to 5%, with SLS5%DL demonstrating optimal dry latex deposition and sustained-release characteristics after annealing (60 °C, 75% RH, 6 h). Higher SLS levels (10%) reduced adhesiveness and coating quality.
This research highlights SLS's critical role as a surfactant in stabilizing polymer particles during freeze drying, facilitating uniform coating without solvents or heating. The enhanced coating performance enables controlled drug release over 2 hours, showcasing an environmentally friendly, efficient approach for pharmaceutical tablet coating applications.

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