• Home
• Services
• Nano-Lipid Carrier Services
• Liposome Services
• Liposome Encapsulation Services
• Imaging & Labeling Agent Encapsulation

Precision Visualization Through Advanced Liposomal Technology

In the rapidly evolving landscape of molecular imaging and precision medicine, the efficacy of diagnostic probes is frequently constrained by rapid systemic clearance, signal attenuation, photophysical instability, and off-target background interference. Alfa Chemistry provides specialized imaging & labeling agent encapsulation services designed to transform labile molecular markers into stable, high-contrast liposomal imaging formulations suitable for preclinical and translational research.

Leveraging the structural adaptability of phospholipid bilayers, we protect sensitive labeling agents from premature degradation, minimize nonspecific interactions, and enable controlled biodistribution with optional surface functionalization for targeted delivery. Our services support advanced investigations in oncology, neurology, cardiovascular research, metabolic studies, and molecular diagnostics.

Comprehensive Encapsulation Capabilities

We deliver customized encapsulation solutions for a broad range of imaging modalities. Each formulation is rationally engineered to maximize payload retention, colloidal stability, signal integrity, and biological compatibility by strategically localizing agents within the aqueous core or lipid bilayer according to their physicochemical properties.

1. Optical & Fluorescence Imaging

Encapsulation of high-quantum-yield fluorophores (e.g., FITC, Cy5.5, ICG) and quantum dots.

• Technical Advantage: Optimized lipid-to-dye ratios and internal microenvironment control reduce self-quenching and photobleaching, enabling extended real-time biological tracking.

2. Magnetic Resonance Imaging (MRI)

Integration of paramagnetic contrast agents such as Gadolinium chelates or Superparamagnetic Iron Oxide Nanoparticles (SPIONs).

• Technical Advantage: By modulating membrane permeability and chelate positioning within the liposome, we enhance relaxivity performance and prolong systemic circulation for improved vascular and tumor imaging contrast.

3. Nuclear Imaging (PET/SPECT)

Remote loading or surface conjugation strategies for radioisotopes such as ⁶⁴Cu, ⁸⁹Zr, and ¹¹¹In.

• Technical Advantage: Radioliposome systems enable quantitative pharmacokinetic profiling and highly sensitive biodistribution mapping in preclinical imaging studies.

4. Stable Isotope Labeling

Incorporation of deuterated lipids or ¹³C- and ¹⁵N-labeled metabolites for LC–MS-based analysis.

• Technical Advantage: Provides a non-radioactive approach for metabolic flux investigation and long-term quantitative tracking.

Technical Advantages: Why Liposomal Encapsulation?

Service Workflow

Supporting Theranostic Research

We also provide co-encapsulation services for imaging agents alongside therapeutic compounds, enabling synchronized evaluation of biodistribution and treatment response in preclinical models.